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Preparing Clinexia…
Preparing Clinexia…
Typical reference ranges, formulas, and unit definitions used throughout Clinexia.
| Analyte | Typical range | Unit |
|---|---|---|
| Hemoglobin (male) | 13.3-18.0 | g/dL |
| Hemoglobin (female) | 12.0-16.0 | g/dL |
| Hematocrit (male) | 40.0-54.0 | % |
| Hematocrit (female) | 36.0-46.0 | % |
| WBC count | 4.5-11.0 | x10⁹/L |
| RBC count (male) | 4.5-5.9 | 10¹²/L |
| RBC count (female) | 4.0-5.2 | 10¹²/L |
| Platelet count | 150-400 | x10⁹/L |
| MCV | 80-100 | fL |
| MCH | 27-33 | pg |
| MCHC | 32-36 | g/dL |
| Neutrophils | 40-70 | % |
| Lymphocytes | 20-40 | % |
| Absolute neutrophil count | 1.5-8.0 | 10⁹/L |
| Analyte | Typical range | Unit |
|---|---|---|
| Glucose, fasting | 70-120 | mg/dL |
| BUN | 7-20 | mg/dL |
| Urea | 10-50 | mg/dL |
| Creatinine | 0.2-1.4 | mg/dL |
| Sodium | 135-145 | mmol/L |
| Potassium | 3.5-5.0 | mmol/L |
| Chloride | 96-108 | mmol/L |
| Bicarbonate (CO₂) | 22-32 | mmol/L |
| Calcium, total | 8.5-10.5 | mg/dL |
| Total protein | 6.0-8.3 | g/dL |
| Albumin | 3.5-5.0 | g/dL |
| Total bilirubin | 0.2-1.3 | mg/dL |
| ALT | <41 | U/L |
| AST | <31 | U/L |
| Total cholesterol | <200 (desirable) | mg/dL |
| LDL cholesterol | 50-150 (optimal) | mg/dL |
| HDL cholesterol | 40-80 | mg/dL |
| Triglycerides | 60-180 | mg/dL |
| TSH | 0.4-4.0 | mIU/L |
BMI (Body Mass Index)
BMI = weight (kg) / height (m)²
Body Surface Area
BSA (m²) = sqrt[(height(cm) x weight(kg)) / 3600]
Ideal Body Weight
Male: 50 + 2.3 x (height in inches - 60) Female: 45.5 + 2.3 x (height in inches - 60)
Basal Metabolic Rate
Male: 10W + 6.25H - 5A + 5 Female: 10W + 6.25H - 5A - 161
Adjusted Body Weight
AdjBW = IBW + 0.4 x (Actual Weight - IBW)
Estimated Calorie Requirement (TDEE)
TDEE = BMR (Mifflin-St Jeor) x Activity Factor
Waist-to-Height Ratio
WHtR = Waist circumference / Height (same units)
Waist-to-Hip Ratio
WHR = Waist circumference / Hip circumference (same units)
Creatinine Clearance (Cockcroft-Gault)
CrCl = [(140 - age) x weight(kg)] / (72 x Scr(mg/dL)) x (0.85 if female)
eGFR (CKD-EPI 2021)
eGFR = 142 x min(Scr/κ,1)^α x max(Scr/κ,1)^-1.200 x 0.9938^Age x (1.012 if female)
BUN/Creatinine Ratio
BUN/Cr ratio = BUN (mg/dL) / Creatinine (mg/dL)
eGFR (MDRD)
eGFR = 175 x Scr^-1.154 x Age^-0.203 x (0.742 if female)
Fractional Excretion of Sodium
FeNa (%) = (Urine Na x Plasma Cr) / (Plasma Na x Urine Cr) x 100
Fractional Excretion of Urea
FeUrea (%) = (Urine Urea x Plasma Cr) / (Plasma Urea x Urine Cr) x 100
LDL Cholesterol (Friedewald)
LDL = TC - HDL - TG/5 (mg/dL) or TC - HDL - TG/2.2 (mmol/L)
Non-HDL Cholesterol
Non-HDL = TC - HDL
VLDL Estimation
VLDL = TG / 5 (mg/dL)
Anion Gap
AG = Na - (Cl + HCO3); Corrected AG = AG + 2.5 x (4 - albumin[g/dL])
Corrected Calcium
Corrected Ca (mg/dL) = Measured Ca + 0.8 x (4 - Albumin[g/dL])
Total Cholesterol/HDL Ratio
TC/HDL ratio = Total Cholesterol / HDL
Calcium-Phosphate Product
Ca x PO4 product (mg²/dL²) = Calcium (mg/dL) x Phosphate (mg/dL)
LDL/HDL Ratio
LDL/HDL ratio = LDL / HDL
Delta Gap / Delta Ratio
Delta Gap = AG - 12 Delta Ratio = Delta Gap / (24 - HCO3)
Estimated Serum Osmolality
Osm (mOsm/kg) = 2 x Na + Glucose/18 + BUN/2.8
HbA1c ↔ Estimated Average Glucose
eAG (mg/dL) = 28.7 x HbA1c(%) - 46.7
Corrected Sodium for Hyperglycemia
Corrected Na = measured Na + correction factor × ((glucose − 100) / 100)
Urea ↔ BUN Conversion
Albumin-Corrected Anion Gap
Corrected AG = AG + 2.5 × (4.0 − albumin[g/dL])
Creatinine Unit Conversion
Red Cell Indices
MCV = (Hct × 10) / RBC; MCH = (Hgb × 10) / RBC; MCHC = (Hgb / Hct) × 100
Absolute Cell Count
Absolute count = WBC(x10⁹/L) x (differential % / 100)
Corrected WBC Count
Corrected WBC = (Uncorrected WBC x 100) / (100 + nRBC per 100 WBC)
Hematocrit Estimation
Hct (%) ≈ Hgb (g/dL) x 3
International Normalized Ratio
INR = (PT / mean normal PT)^ISI
Platelet Corrected Count Increment
CCI = platelet increment (/µL) × BSA (m²) ÷ platelet dose (×10¹¹)
Estimated Blood Volume
International Prognostic Index
Reticulocyte Production Index
RPI = reticulocyte % × (patient Hct / reference Hct) ÷ maturation factor
aPTT Ratio
aPTT ratio = patient aPTT ÷ control aPTT
Estimated RBC Transfusion Volume
RBC volume ≈ EBV × (target Hct − current Hct) ÷ product Hct
Revised International Prognostic Index
CFU/mL Estimation
CFU/mL = (colonies counted / volume plated[mL]) x dilution factor
Dilution Factor
Dilution factor = final volume / initial (aliquot) volume
Concentration After Dilution
C2 = C1 / dilution factor
Serial Dilution Total Factor
Total dilution factor = factor₁ × factor₂ × ... × factorₙ
Microbiology Concentration After Dilution
Final concentration = initial concentration ÷ dilution factor
Pooled CFU/mL Estimation
CFU/mL = total colonies ÷ total plated volume × dilution factor
Molarity Calculator
Molarity (M) = mass (g) / [molecular weight (g/mol) x volume (L)]
Normality Calculator
Normality (N) = mass (g) / [equivalent weight (g/eq) x volume (L)]
C1V1 = C2V2 Dilution
C1 × V1 = C2 × V2
Percent Solution Preparation
% w/v = g per 100 mL; % v/v = mL per 100 mL; % w/w = g per 100 g
Molar Solution Preparation
Mass (g) = target molarity × molecular weight × final volume (L)
Reagent Dilution & Solvent Volume
V1 = C2V2/C1; solvent = V2 − V1
Beer–Lambert Law
A = εlc
Absorbance ↔ Transmittance
A = −log10(T), T = 10^(−A), %T = 100T
Spectrophotometry Standard Curve
y = mx + b; x = (y − b)/m
Spectrophotometry Dilution-Corrected Concentration
Original concentration = [(A − b)/m] × dilution factor
Wavelength ↔ Frequency
f = c / λ
Photon Energy from Wavelength
E = hc / λ
Wavelength ↔ Wavenumber
ṽ (cm⁻¹) = 10⁷ / λ(nm)
Blank-Corrected Absorbance
A(corrected) = A(sample) − A(blank)
Spectrophotometry Replicate Statistics
Mean = Σx/n; SD = sample standard deviation; CV% = SD/Mean × 100
Spectrophotometry Calibration Regression
y = mx + b; R² = 1 − SSres/SStot; x = (y − b)/m
Photometric Linearity Check
Deviation (%) = (Observed − Expected) / Expected × 100
Weight-Based Dose (mg/kg)
Dose (mg) = prescribed dose (mg/kg) × weight (kg)
Oral Liquid Dose Volume
Volume (mL) = required dose (mg) ÷ concentration (mg/mL)
Tablet/Capsule Dose Count
Units = required dose ÷ strength per unit
Dose Volume Rounding
Rounded volume = exact volume adjusted to the selected measuring increment
Weight-Based Daily Dose (mg/kg/day)
Daily dose (mg/day) = prescribed dose (mg/kg/day) × weight (kg)
Body Surface Area Dose (mg/m²)
Dose (mg) = prescribed dose (mg/m²) × BSA (m²)
Dose per Administration
Dose per administration = total daily dose ÷ administrations per day
Dose to Volume
Volume (mL) = required dose (mg) ÷ concentration (mg/mL)
Drug Concentration
Concentration (mg/mL) = drug amount (mg) ÷ final volume (mL)
Infusion Rate
Rate (mL/hr) = volume (mL) ÷ time (hr)
IV Drops per Minute
Drops/min = volume(mL) × drop factor(gtt/mL) ÷ time(min)
Maximum Dose Check
Final dose = min(calculated dose, specified maximum)
Artesunate to Severe Malaria
WHO dose: 3 mg/kg per dose for children <20 kg; 2.4 mg/kg per dose for patients ≥20 kg
Artemether–Lumefantrine to Uncomplicated Malaria
Weight band to tablets per dose; 6 doses at 0, 8, 24, 36, 48 and 60 hours
Artesunate–Amodiaquine to Uncomplicated Malaria
Weight band to fixed-dose combination per day for 3 days
Artesunate–Mefloquine to Uncomplicated Malaria
Weight band to fixed-dose combination per day for 3 days
Dihydroartemisinin–Piperaquine to Uncomplicated Malaria
Weight band to fixed-dose combination once daily for 3 days
Artesunate–Sulfadoxine/Pyrimethamine to Uncomplicated Malaria
Weight band to artesunate daily for 3 days + single SP dose on day 1
Artesunate–Pyronaridine to Uncomplicated Malaria
Weight band to fixed-dose combination once daily for 3 days
Amoxicillin to Pediatric Dose
Daily dose = 25–50 mg/kg/day × weight; divided into 3 doses/day
Amoxicillin/Clavulanate to Pediatric Dose
Amoxicillin component = 25–50 mg/kg/day × weight; divided 3 times daily
Azithromycin to Pediatric Dose
Dose = 10 mg/kg once daily
Ceftriaxone to Pediatric Dose
General dose = 50 mg/kg/day; meningitis = 100 mg/kg/day
Cephalexin to Pediatric Dose
Daily dose = 50–100 mg/kg/day × weight; divided into 4 doses
Metronidazole to Pediatric Dose
Daily dose = 15–30 mg/kg/day × weight; divided into 2 doses
Cefuroxime to Surgical Prophylaxis
Dose = 50 mg/kg × weight
Ampicillin to Pediatric Dose
Dose = 50 mg/kg per administration
Cefotaxime to Pediatric Dose
Dose = 50 mg/kg per administration
Cloxacillin to Pediatric Dose
Neonates: 25–50 mg/kg/dose q12h; children: 25 mg/kg/dose q6h
Ciprofloxacin to Pediatric Dose
Weight band to fixed dose every 12 hours
Gentamicin to Pediatric Dose
Neonates: 5 mg/kg/dose; children: 7.5 mg/kg/dose
Meropenem to Pediatric Dose
Dose = 20 mg/kg per administration every 8 hours
Vancomycin to Pediatric Dose
Dose = 15 mg/kg per administration
Amoxicillin/Clavulanate to Renal Adjustment
GFR >30: usual regimen; GFR 10–30: 250 or 500 mg q12h; GFR <10: 250 or 500 mg q24h
Ciprofloxacin to Renal Adjustment
CrCl >50: q12h; 30–50: q12h; 5–29: q18h; dialysis: q24h after dialysis
Cefotaxime to Renal Adjustment
CrCl ≥20: usual dose; CrCl <20: 50% of usual dose
Cefuroxime Axetil to Renal Adjustment
CrCl ≥30: no adjustment; 10–<30: q24h; <10: q48h; hemodialysis: extra standard dose after dialysis
Meropenem to Renal Adjustment
CrCl >50: usual q8h; 26–50: usual q12h; 10–25: half-dose q12h; <10: half-dose q24h
Vancomycin to AUC24 Target Check
Target AUC24 = 400–600 mg·h/L (assuming MIC = 1 mg/L)
Gentamicin to Peak/Trough Check
Conventional reference: peak 4–6 mcg/mL (adult) or 3–5 mcg/mL (pediatric); trough <2 mcg/mL
WHO 0–59 Days to Sepsis/Pneumonia Regimen
Ampicillin 50 mg/kg/dose + gentamicin 5 or 7.5 mg/kg once daily
WHO 0–59 Days to Meningitis Regimen
Ampicillin 50 mg/kg/dose or cefotaxime 50 mg/kg/dose or ceftriaxone 100 mg/kg + gentamicin
Piperacillin–Tazobactam to Pediatric Dose
Piperacillin dose = 100 mg/kg/dose × weight; IV every 8 hours
Clindamycin to Pediatric Dose
Neonate: 5 mg/kg/dose q8h; child: 10 mg/kg/dose q8h
Cefazolin to Pediatric Dose
Dose = 25 mg/kg/dose IV every 12 hours
Linezolid to Pediatric Dose
Dose = 10 mg/kg/dose IV/ORAL every 8 hours
Doxycycline to Pediatric Dose
Day 1: 2 mg/kg/dose twice daily; then 2 mg/kg once daily; maximum 100 mg/dose and 200 mg/day
Loading Dose
Loading dose = loading dose rate (mg/kg) × weight (kg)
Maintenance Dose
Dose per administration = total daily dose ÷ administrations per day
Infusion Duration
Time (hours) = volume (mL) ÷ rate (mL/hour)
Course Total Dose
Total course dose = dose per administration × administrations per day × treatment days
WHO Pediatric Pneumonia to Regimen Reference
Dose = 40 mg/kg per dose × weight; twice daily
WHO Pediatric Diarrhoea to Zinc Regimen
Zinc = 5 mg elemental zinc once daily; duration = 10–14 days
WHO Pediatric ORS to Plan B Volume
ORS volume = 75 mL/kg × body weight; administer over 4 hours
WHO Pediatric ORS to Ongoing Losses
<2 years: 50–100 mL per loose stool; 2–<10 years: 100–200 mL per loose stool; ≥10 years: as much as wanted
WHO Pediatric Maintenance IV Fluid
4 mL/kg/hour for first 10 kg + 2 mL/kg/hour for next 10 kg + 1 mL/kg/hour for each subsequent kg
Pediatric Fluid Deficit to Assessed Dehydration
Deficit (mL) = weight (kg) × dehydration (%) × 10
Oncology BSA-Based Dose
BSA (m²) = √[(height cm × weight kg) ÷ 3600]; dose (mg) = protocol dose (mg/m²) × BSA
Chemotherapy Dose Intensity
Dose intensity = cumulative dose (mg/m²) ÷ treatment duration (weeks)
Relative Dose Intensity
RDI (%) = delivered dose intensity ÷ planned dose intensity × 100
Chemotherapy Cumulative Dose
Cumulative dose = dose/administration × administrations/cycle × cycles
Chemotherapy Cycle Total
Cycle total = dose/administration × scheduled administrations
Carboplatin Dose to Calvert Formula
Dose (mg) = target AUC × (GFR + 25)
Chemotherapy Dose Cap Check
Final dose = min(calculated dose, protocol maximum)
Oncology Regimen to Patient-Specific Dose
Oncology Haematologic Dose-Modification Assessment
Oncology Renal & Hepatic Dose-Modification Assessment
Oncology Toxicity / Safety Assessment
Chemotherapy Emetogenic Risk Assessment
Febrile Neutropenia Prophylaxis Risk Assessment
Risk band = estimated febrile-neutropenia probability
Oncology Cycle Progress
Remaining cycles = planned cycles − completed cycles; course progress (%) = completed cycles ÷ planned cycles × 100
Oncology Course Completion
Completed exposure = dose/cycle × completed cycles; remaining planned exposure = dose/cycle × remaining cycles
Mean Arterial Pressure
MAP ≈ (SBP + 2 × DBP) ÷ 3
Left Ventricular Ejection Fraction
EF (%) = (EDV − ESV) ÷ EDV × 100
CHA₂DS₂-VASc Score
DAPT Score
QTc Correction
Atherogenic Index of Plasma
AIP = log10(TG / HDL-C)
Pulse Pressure
Pulse pressure = SBP − DBP
Cardiac Index
Cardiac index = cardiac output ÷ BSA
HAS-BLED Bleeding Risk Score
Atrial Fibrillation Ventricular Rate
Rate (bpm) = QRS count × 60 ÷ strip duration (seconds)
HCT-Specific Comorbidity Index
Conditioning / Transplant Day Tracker
Stem Cell Collection Yield
Dose (×10⁶/kg) = CD34 concentration (cells/µL) × product volume (mL) ÷ 1,000,000 ÷ weight (kg) × 1,000
CD34+ Cell Dose
CD34 dose (×10⁶/kg) = total CD34+ cells (×10⁶) ÷ weight (kg)
Neutrophil Engraftment Timing
Donor Chimerism
Donor chimerism (%) = donor signal ÷ total signal × 100
Stem Cell Collection Target
Target CD34+ cells = target dose (×10⁶/kg) × weight (kg)
Viable CD34+ Cell Dose
Viable dose = total CD34+ cells × viability ÷ weight
Engraftment Duration
Elapsed days = engraftment day − transplant day
C1 x V1 = C2 x V2
% w/v = g solute / 100 mL solution % v/v = mL solute / 100 mL solution % w/w = g solute / 100 g solution
A = ε b c
A = -log₁₀(T)